Earlier, title holder Borna Coric beat American Sebastian Korda 7-6 (5), 6-4, while another home hope Taylor Fritz survived a first-set thriller to beat Czech Jiri Lehecka 7-6 (14), 6-2.
Rafael Nadal's hopes of completing a rare calendar year Grand Slam ended on Thursday when the Spaniard pulled out of his highly-anticipated Wimbledon semi-final showdown against Australian Nick Kyrgios with an abdominal strain.
World number one Novak Djokovic eased past Greek Stefanos Tsitsipas 6-3, 6-4 to lift his fifth Dubai Tennis Championships title on Saturday, extending his unbeaten start to the 2020 season. Djokovic has now won 21 straight matches, including 18 this season, having already lifted the inaugural ATP Cup with Serbia and a record-extending eighth Australian Open title last month.
This year's US Open runs from Aug. 28-Sept. 10.
Here is a quick glance of all the highs and lows from Nadal's stupendous career:
The Australian was warned for bad language and docked a point for unsportsmanlike conduct after throwing his racquet into the stands during Friday's 6-3, 6-4 defeat by Borna Coric in the Murray River Open at Melbourne Park.
World number one Novak Djokovic was furious with the chair umpire for not suspending play as rain trickled down during his Italian Open second-round match against American Taylor Fritz.
Madison Keys swept past Wimbledon champion Elena Rybakina 6-2, 6-4 at the Cincinnati Open on Friday, setting up a semi-final clash with Petra Kvitova after the Czech defeated Ajla Tomljanovic.
Nadal to make injury return at Madrid Open
Zverev's brother Mischa Zverev was also eliminated, going out 6-3, 6-1 to David Ferrer in the first round, while Kei Nishikori eased to a 7-5, 6-2 win over Taylor Fritz to secure a place in the third round.
Novak Djokovic and Serena Williams were named men's and women's world champions for 2015 by the International Tennis Federation on Tuesday. The Serb ended the year as men's world number one for the fourth time after taking three majors - the Australian, Wimbledon and US Open, as well as finishing runner-up to Stan Wawrinka in the French. Williams also narrowly missed a calendar-year grand slam, winning the Australian, French and Wimbledon and reaching semi-final at US Open.
Gauff survives scare, Osaka advances
Novak Djokovic and Serena Williams were named men's and women's world champions for 2015 by the International Tennis Federation.
Vasek Pospisil and Denis Shapovalov clinched the winning point for Canada with a 2-6, 6-3, 6-3 triumph over Kevin Krawietz and Tim Puetz in the decisive doubles match.
Murray knocked out by Fritz in Washington
After the 'lingerie' outfit during the Wimbledon, Nike is back with fluorescent yellow gear for players, both male and female.
World number one Jannik Sinner's bid for a second Grand Slam title continued to gain momentum as he thumped Christopher O'Connell 6-1, 6-4, 6-2 on Saturday to reach the US Open fourth round.
Coco Gauff rallied from a break down in the final set to beat Swede Rebecca Peterson and reach the Indian Wells quarter-finals for the first time
Yuki Bhambri's maiden appearance at the French Open ended with a first round defeat as he lost his opening men's singles match to Belgium's Ruben Bemelmans in straight sets, in Paris, on Tuesday.
Federer, 39, was pushed to the limit in his first match back on Wednesday when he beat Briton Dan Evans in three sets but the Swiss looked well in control in the opening set against the unseeded Basilashvili.
Big-serving John Isner bid farewell to his professional career after losing to fellow American Michael Mmoh in the US Open second round.
Russian Daniil Medvedev's 2022 season opened with a stunning defeat at the hands of Frenchman Ugo Humbert after a three-hour dogfight in a steamy Ken Rosewall Arena at the ATP Cup on Sunday.
Novak Djokovic produced a stunning performance to thrash Frances Tiafoe in his first match since winning Wimbledon in July to edge Team Europe ahead in the Laver Cup on Saturday.
Alexander Zverev continued to rebuild his confidence on clay with a straight sets win over Spain's Roberto Bautista Agut in the Monte Carlo Masters second round.
Carlos Alcaraz swatted aside Serbian Dusan Lajovic as Canadian Bianca Andreescu cruised past American Sofia Kenin in straight sets at Miami Open.
Eighth-seeded Madison Keys was forced to stay up late before overcoming fellow American Alison Riske to close out Monday's play at Arthur Ashe Stadium on a busy opening day for the home contingent at the US Open.
Kyrgios added that he had been in communication with Tennis Australia chief executive Craig Tiley and United Cup tournament director Stephen Farrow about his injury.
Surprise package Davidovich Fokina, who knocked out top-ranked Novak Djokovic and Indian Wells champion Taylor Fritz in the earlier rounds at Monaco, drew first blood by breaking Tsitsipas to take a 2-1 lead in the opening set.
'I'm disappointed and sad because after a good start to the season I was coming to a very important part of the year with very good feelings and good results.'
World number one Carlos Alcaraz sailed into the Paris Masters third round with a 6-4, 6-4 win over Yoshihito Nishioka but Rafael Nadal and Daniil Medvedev both slumped to surprise losses on Wednesday.
Holder Stefanos Tsitsipas moved into the Monte Carlo Masters quarter-finals with a 7-5, 7-6(1) victory over Laslo Djere on Thursday while fourth seed Casper Ruud was knocked out in straight sets by Grigor Dimitrov.
Sabalenka overpowers Raducanu, Osaka falls
As a sporting spectacle Alcaraz and Djokovic matches have delivered on every level and would be worthy of the Big Apple spotlight.
Defending champion Stefanos Tsitsipas came out on top from a thrilling quarter-final clash with Diego Schwartzman, prevailing 6-2, 6-7(3), 6-4 on Friday to set up a meeting with Alexander Zverev at the Monte Carlo Masters.
Since 2003, one of Roger Federer, Novak Djokovic, Rafael Nadal or Andy Murray have won the title at Wimbledon, with the Swiss leading the way with eight titles.
Nadal believes he had no reason to feel alarmed ahead of the season's first Grand Slam starting in two weeks.
In the ongoing Monte Carlo Masters, Jannik Sinner clinched a hard-fought win as Casper Ruud crashed out.
Novak Djokovic has no intention of passing the torch to the next generation just yet.
Homeland favorite Ashleigh Barty and Serbia's Novak Djokovic are the top seeds for the upcoming Australian Open.
Dominic Thiem and Stefanos Tsitsipas won their respective singles matches before Roger Federer and Alexander Zverev teamed up in the doubles to beat Jack Sock and Denis Shapovalov
